The catechol moiety of obafluorin is essential for antibacterial activity
نویسندگان
چکیده
Complex formation with ferric iron protects the β-lactone moiety of obafluorin from hydrolysis and potentiates antibiotic activity.
منابع مشابه
Synthesis and antibacterial activity of novel carbapenems with a catechol or hydroxypyridone moiety.
in chemotherapy. Recently there are manyreports detailing with /Mactams containing the catechol moiety1~5). In addition, it has also been reported that the introduction of a monoor dihydroxypyridone moiety6~ 12) instead of a catechol group as an isostere is effective in improving stability against catechol-0-methyltransferase (COMT)6). Such compounds show marked activity against Gramnegative or...
متن کاملAntibacterial activity of the essential oils of endemic plants
Background & Aim: Secondary metabolites with bioactive and functional properties in essence of aromatic plants can be useful for improvement of quality and persistence of food as natural preservative. The aim of this study was to evaluate the in vitro antibacterial of essential oils of some of the medicinal plants collected from Chaharmahal va Bakhtiari Province, Iran. Experimental: ...
متن کاملAntibacterial activity of the essential oils of endemic plants
Background & Aim: Secondary metabolites with bioactive and functional properties in essence of aromatic plants can be useful for improvement of quality and persistence of food as natural preservative. The aim of this study was to evaluate the in vitro antibacterial of essential oils of some of the medicinal plants collected from Chaharmahal va Bakhtiari Province, Iran. Experimental: ...
متن کاملSynthesis and in vitro antibacterial activity of catechol-spiramycin conjugates.
The first synthesis of siderophore conjugates of two macrolide antibiotics, spiramycin 1 and neospiramycin 2, which are unable to penetrate the outer membrane of gram-negative bacteria are described. These novel conjugates were prepared by regioselective acylation of a hydroxyl function of 1 and 2 with a dihydroxybenzoic Fe(III) complexing ligand linked via a carboxyl group containing spacer to...
متن کاملSynergic antibacterial activity of some essential oils from Lamiaceae
Background and objectives: Despite the vast production of new antibiotics in the last three decades, resistance to these drugs by microorganisms has increased and essential oils (EOs) have been recognized to possess antimicrobial properties. Methods: In the present study, EOs obtained from aerial parts of Thymus vulgaris L., Lavandula angustifolia Mill., Rosmarinus offici...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: RSC chemical biology
سال: 2023
ISSN: ['2633-0679']
DOI: https://doi.org/10.1039/d3cb00127j